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Calcium and magnesium - vital to health Darrell Miller 12/20/12
What Form Of Calcium Is The Best Calcium? Darrell Miller 2/21/12
Which Form Of Calcium Is Best For You? Darrell Miller 1/15/08
Looking For A Calcium But Not Sure Which Is Best For You? Darrell Miller 11/2/07
Which Calcium is Best? Darrell Miller 10/17/06
Benefits of Total Daily Formula Darrell Miller 10/13/05



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Calcium and magnesium - vital to health
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Date: December 20, 2012 02:06 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Calcium and magnesium - vital to health

Calcium and magnesium are two essential minerals for the body, bringing serious damage if there is a deficiency. Calcium is essential for maintaining bone strength in the body, but also for the functioning of nerve and muscle cells.

Bones perform several roles in the body, but most of us are interested in the preservation of acid-base balance (pH). When the pH of the blood is too acidic , bone alkaline elements released (alkali salts) to neutralize acids. This leads to loss of bone mass (and calcium), while rapidly releasing toxins and heavy metals stored in bone if there are metals and toxins present.

Most of us know that calcium is found in dairy products. True, but the information is not complete. You should know that of all dairy products, yogurt offers the most calcium, about 200 mg in a cup. But if you want the most bioavailable calcium, ie one that is most easily absorbed and can be used fully by the body, then you need to take calcium citrate.

If the food based calcium intake is not optimal and extremely diverse, then you need calcium-based vitamin supplement products. Calcium supplements may be consumed with meals for maximum digestion and absorption. But even if you take dietary supplements, diet should not remain poor, continue to get adequate amounts of calcium from food sources.

Magnesium has an important role in the efficient functioning of the nervous system, muscular system and  enzyme processes in the body. It is necessary for calcium absorption. The ratio of the two minerals is especially important. An adult daily needs for bone health by around 1,500 mg of calcium and 1000 mg of magnesium. Bones are living tissues that rebuild constantly. A healthy diet, exercise, enough sleep (at least 8 hours) and keeping well hydrated with water helps strengthen bones. Calcium and magnesium, combined doubles benefits to our body, especially if they are of citrate in origin. 

Cal-Mag Citrate Why?

Studies have shown that calcium and magnesium citrate is the easiest form to digest with minimal stomach acids. This make it work great for older individuals who have low stomach acids or who are on proton pump inhibitors. 

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What Form Of Calcium Is The Best Calcium?
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Date: February 21, 2012 11:21 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: What Form Of Calcium Is The Best Calcium?

Best Calcium

Manypeople these days want to know which form of calcium is the best form of calcium. Calcium happens to be an essential nutrient for the body. However, since this nutrient serves a variety of purposes, therefore, it can be a bit tricky to determine which form is the best. There, in fact, might not be a single best form of calcium but probably quite a few, depending on what the calcium is needed for.

Calcium Complex (MCHA) Microcrystalline Hydroxyapatite

Everyone is aware that calcium is the building block of bones and for the treatment of a bone-related condition like osteoporosis; Calcium Complex (MCHA) Microcrystalline Hydroxyapatite is the best calcium. Supplements containing this form of calcium have, in fact, been proven to be effective at increasing bone density and reversing osteoporosis. Among the biological forms of calcium available, what makes MCHA one of the best forms of calcium for treating osteoporosis and increasing bone density is because it is excellent absorbed by the body. Calcium carbonate is often recommended by medical doctors because a very minimal amount of pills need to be taken.

Calcium Carbonate

For those who do not want to use a form of calcium derived from a biological, animal source and are, in fact, in search of the best calcium for the maintenance of bones, then Calcium Carbonate is perfect. This form of calcium is the second best in regards to absorption by the body. Calcium Carbonate is often recommended by medical doctors because a very minimal amount of pills need to be taken. Calcium Carbonate supplements can be found quite easily and they are mostly affordably priced.

Chelated Calcium

Supplementing calcium also becomes necessary for anyone who has recently undergone Bariatric surgery. While Calcium Carbonate can also be used in such a situation, however, the best calcium in this case would be Chelated Calcium. Chelated Calcium is a form of calcium that is used in combination with beneficial amino acids. In comparison to Calcium Carbonate, research has shown that Chelated Calcium is a far more biologically available form of calcium. However, the dosages of this calcium that need to be taken are generally quite large. Above all, Chelated Calcium supplements can be quite costly too.

calcium citrate

calcium citrate is an ideal alternative to Chelated Calcium, in fact, it is another form of Chelated Calcium, but the supplements that contain this form of calcium are usually more inexpensive. Not only this, those who choose to use this form of calcium will also get to take lower dosages. calcium citrate is a form of calcium that is acid based and is quite capable at supplementing the body with calcium since it is quite effectively absorbed. Since no additional stomach acid is required for the absorption of this form of calcium, therefore, calcium citrate at just about any time.

There are many other forms of calcium that are quite ideal for the body as well and can prove to be beneficial as well. This is the reason that those in search of the best calcium will come across numerous choices and some of the best ones were mentioned here.

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Which Form Of Calcium Is Best For You?
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Date: January 15, 2008 05:10 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Which Form Of Calcium Is Best For You?

There is no warning signal that lets you know if you have a calcium deficiency. Actually, a calcium deficiency is usually undetectable until damage that is irreversible has already occurred. A calcium deficiency is extremely hard to detect because the calcium level in the blood may seem to be normal, even if extreme cases of deficiency are actually occurring. This is because the body has a calcium bank, which can be found in teeth and bones. Calcium is needed in order to control muscular contractions such as the heart, blood-clotting, transmission of nerve impulses, and other requirements which take priority.

You may not know for sure whether you have calcium deficiency until you experience loose teeth, receding gums, or a bone fracture. At this point you will realize how brittle and chalky your bones have become. There is no known cure for osteoporosis, and it seems to be affecting people at younger ages more and more. The progression towards this illness takes years, but it is going on unnoticed in a great percentage of our population right as we speak.

There are many reasons why calcium deficiency is so widespread. First, calcium is not easily absorbed, as no more than 10-20% of what is found in foods is actually consumed and metabolized. This is because a meal that is high in fats can form insoluble calcium soaps which cause calcium to pass through the system without being absorbed. Also, the calcium in certain vegetables can actually be inhibited from releasing by oxalates that are found naturally in foods such as rhubarb, kale, spinach, broccoli, grains, and cereals.

Furthermore, vitamins A and D must be present in the body in order for absorption to occur. Additionally, calcium requires an acid environment for absorption, which is a huge problem for older people who have less production of digestive acids. More so, amino acids are needed for the formation of calcium-amino acid complexes and magnesium and phosphorus must be present in a precise ratio’s. Without all of these factors, you can lose a lot of the benefit, no matter how much calcium you are taking in.

A great variety of calcium supplements can be found in your health food store. These supplements can range from a simple calcium carbonate to bone meal, dicalcium phosphate, dolomite, calcium lactate, calcium gluconate, and many others. Although they all contain calcium, they vary in the amount of actual calcium content from 40% in calcium carbonate to 9% in calcium gluconate. Calcium carbonate has the highest percentage calcium per gram, but it acts as an antacid which makes this supplement somewhat useless since calcium can only be absorbed in an acid environment.

Acid breaks down the bonds between the calcium element and its bonding partner like carbonate or amino acid chelate. Calcium Carbonate has a carbon bond the strongest bond of its kind; this makes it extremely unwise for those people who are older or suffer from a digestive acid deficiency. Calcium carbonate that is derived from oyster shells is no different from any other form. However, oyster shells carry an additional risk of being contaminated with naturally occurring heavy metals found in the oyster bed environment. Calcium phosphate is probably the best source of calcium, since the principle calcium in the body is actually calcium hydrogen phosphate which is easy to digest.

Whether you choose calcium carbonate or calcium citrate, ask your local health food store which calcium is best for you depending on your age and whether you have a digestion disorder or not. With poor diets and lack of exercise, calcium supplementation is a must for most people. Have you had your calcium today?



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Looking For A Calcium But Not Sure Which Is Best For You?
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Date: November 02, 2007 12:23 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Looking For A Calcium But Not Sure Which Is Best For You?

Calcium is essential to good health, but if you are looking for calcium it can be confusing to decide in which form you take it. There are so many available and every one claims to be good for you, so why the difference? Why not just sell the best and let us all know what it is? Well, this same argument could be applied to all supplements that are sold in different forms, and also to many foodstuffs.

The supplement best for you might not be the best for the next person due to dietary requirements each persons diet is different, so it is better to learn about what is available then make your choice based upon knowledge rather than ignorance. It is not only the source of the calcium you have to bother about, but also the other vitamins that have be present to make sure that that the calcium is absorbed by the body in the way that you want it to be.

To understand that then you need to learn why the body needs calcium, other than just the bones and teeth that everybody knows about. After all, why else do we need calcium? It is only contained in bones and teeth – right? Wrong!

Although 99% of calcium is contained in your bones and teeth, 1% is contained in the blood, muscles and central nervous system. With out that 1% we would all die. Without teeth we would not. Calcium is essential for blood clotting and for the proper function of our muscles, brain and central nervous system. Calcium combines with phosphorus to create healthy bones and teeth, and is essential early in life to build up a strong skeleton. Note that phosphorus is also necessary so we also need an adequate supply of that mineral.

Calcium is essential to allow muscles to properly contract. Without that ability, muscles could not work, and a deficiency of calcium causes muscle cramps and spasms. The movement of the smooth muscles is regulated by a protein that is bound to calcium. This is just one of the uses of the calcium in the body that most people are unaware of.

Calcium also takes part in the binding process of the blood platelets during the coagulation of blood. Although most people are aware of the need for vitamin K and fibrin, in fact calcium is also essential in its interaction with the platelets in the coagulation cascade that eventually results in a blood clot that stops bleeding. Basically, without calcium, the blood could not form a clot. In addition to its effect on blood clotting, calcium also plays an essential part in the movement of ions through the membranes of nerve cells, and without it intercellular communication could not occur. Our nerve impulses would not occur and the body again would not be in a working condition.

However, the body has a way of modulating the calcium level in the blood past a minimum level needed for effective nerve cell communication, and below a certain level it can even use the calcium in the bones to divert to the more needy areas of the body. It is therefore not possible for the body to fail through a lack of calcium. The skeleton would disintegrate first. Nevertheless, nobody wants a disintegrating skeleton since that would be counterproductive to effective movement of the body, so a good source of calcium is essential for overall bodily health, not just that of the teeth and the bones.

There are many sources of calcium, but some are more suitable for absorption by the body than others. Chalk, or calcium carbonate, is an excellent source of calcium, but will fail to promote bone growth if your diet does not contain sufficient potassium, vitamin D, magnesium and strontium needed to make it work to build healthy bones. It is the most common on the shelves, and likely the cheapest, but not necessarily the best source. It is basically chalk or limestone, and only 10% of the supplement will actually become available for your body to use.

The bioavailability of a calcium supplement is a figure that indicates how much of the calcium is actually absorbed by the body during digestion. It is important that the supplement is digested and absorbed properly or the calcium will not be available for use. This availability is called the ‘bioavailability’. calcium citrate has a bioavailabilty of 50%, but the size of the citrate part of the molecule is so large that only 10.5% of the molecule is available to the body as calcium. Not much more than the carbonate.

Calcium aspartate is highly soluble and produced by reacting calcium with aspartic acid to form the soluble salt. It is much easier to assimilate and be absorbed by the body than any of the forms above. The amino acid, aspartic acid, delivers the calcium exactly to where it is needed, where it is absorbed and used. Although a bioavailability figure is not available, it is not the amount of calcium that is significant here but the fact that it comes with its own transportation system and is immediately available where needed.

If you want to calculate the availability for yourself, find the molecular weight of the particular calcium product, and then the weight of the calcium contained within it. For example, in calcium carbonate, CaCO3, the molecular weight is 100 (40 + 12 + 3x16) and the atomic weigh of calcium is 40, so the amount of calcium present in 1000g calcium carbonate is 40% or 400g. Only 25% of calcium carbonate is absorbed, so only 10%, or 100g, of calcium is available for each 1000g supplement.

calcium citrate on the hand (Ca3(C6H5O7)2.4H2O) has a molecular weight of 570, so the amount of calcium present is 3*40*100/570 = 21%. Since the bioavailability of calcium citrate is 50%, the amount of calcium available is only 10.5%, or 105g in 1000g citrate. You can carry out the same calculation on all the molecules if you know how much is absorbed by the body.

The bioavailability is calcium aspartate is 85%. Its molecular formula is [C4H6NO2]2Ca, and molecular weight 304. The calcium availability is therefore 40*100/304 = 13.16%. If 85% is absorbed, then 1000g provides 80% of 13.16 x 10 = 115.6g. The aspartate therefore wins it.

Amino acid chelates can also be used as a source of calcium, and its bioavailability is improved tremendously by including vitamin D and magnesium in the supplement. The bioavailability of these calcium chelates are not quoted, but is claimed to be high. Whether or not it is as high as the aspartame is debatable, though it is claimed to be.

Calcium is a very important mineral for human health, and there are several different supplements that can be used. The bioavailability of the calcium is different in each supplement, though the organic forms, calcium aspartate and amino acid calcium chelates appear to be the highest. When looking for a calcium supplement look for one with additional minerals added as mentioned above to help improve absorption and usability by the body.



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Which Calcium is Best?
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Date: October 17, 2006 03:52 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Which Calcium is Best?

Customers walking into a health food store today are faced with a vast array of calcium supplements. They might ask: which one should I pick? Which one is best? Not easy questions to answer. All calcium forms will accomplish the same task: providing your body with a nutrient that it needs to build healthy bones and teeth; however, which form of calcium has the features that you want in a calcium supplement? Looking at shelves of calcium products is kind of like shopping for a car; there are many makes and many models—some are basic and others are more sophisticated.

Fortunately, there are many forms of calcium to satisfy your needs. Like the car lot, a health food store offers many options; therefore, you have to select a calcium product that consumers will feel confident in taking regularly and that will provide the most benefit.

Some consumers have done research and will come armed with information. They have already made choices based on advertising, word-of-mouth or an article they have read. They already know the form of calcium they want, be it a “Ferrari” or a “Ford.” If the client doesn’t have a specific preference: asking these basic questions will help in the selection process:

1. Do you prefer tablets, capsules, softgels, liquid or powder?

  • Tablets are for consumers who want high dosage in fewer pills.
  • Capsules are flavorless and may be easier to swallow than tablets for some.
  • Softgels have a slicker surface and may slide down the throat more easily for some.
  • Liquids are easiest to swallow and are available in different flavors.
  • Powders are flavorless, versatile and can be mixed with food or beverages.

2. Do you have high or low stomach acid?

  • Should you use calcium that has buffering action or a calcium that does not further reduce your stomach acid.

3. Do you have absorption issues?

  • Rapid transit time in the bowels may affect a person’s choice of calcium.

What is calcium?

Calcium (Ca) is one of the most important minerals found in our bones and teeth—99 percent of body calcium is found there. But the calcium molecule does not like to travel alone and, in its more basic state, it comes bounded to carbon (C), Oxygen (O), and/or hydrogen (H) molecules or in more complex form, it is bonded to organic or amino acids that act as stabilizing carriers. On most labels, the amount of calcium listed actually indicates the pure or elemental calcium because it is that amount of the calcium that is deemed important to our daily supplementation, not the complex of the materials with which it is bonded.

Where does calcium come from?

Other than the calcium found in bone, the only natural form of calcium found in nature is calcium carbonate, a calcium molecule bonded to one molecule of carbon and three molecules of oxygen (CaCO3). One of the most common minerals on the face of the earth, calcium carbonate is called calcite, aragonite or vaterite by geologists. In its geological form, it constitutes approximately four percent, by weight, or the earth’s crust.

Commercial sources of calcium carbonate used to make supplements are: limestone, dolomite, oyster cell, egg shell, coral and sea water (have you ever seen that white deposit left by hard water? That’s mostly calcium carbonate). Calcium carbonate is the starting material for all other forms of calcium supplements. From this starting material, calcium can be reduced to more concentrated forms, such as oxide or hydroxide or it can be chelated (bonded) to organic acids and amino acids to help support enhanced absorption.

Lets look more closely at the different forms of calcium that are available as supplements.

Calcium Oxide (CaO): this form is 71 percent elemental calcium and is also called “lime” commercially. This is one of the oldest and most inexpensive forms of calcium used in a variety of commercial applications and it is occasionally used in supplements where space and price are a factor. It sometimes can be found in inexpensive mass market calcium/mineral combinations or multivitamin/mineral products and in a unique algal calcium from Japan. Unfortunately, CaO is a strong alkali that may cause stomach distress, which is why it isn’t often used in health food supplements.

Calcium Hydroxide (CaHO): at 54 percent elemental calcium, it is the next highest source of elemental calcium and is also known commercially as “slaked lime.” It is used where space is an issue. Although it is also a strong alkali, it is more stable than calcium oxide. It is most often used as a component of multi-mineral formulations or in addition to other forms of calcium (i.e., calcium citrate) to provide potency where space is an issue. It is not often used as a single ingredient in health food supplementation. This is for people who want a high dosage of calcium from a minimum amount of pills in multi-mineral formulas.

Calcium Carbonate (CaCO3): at 40 percent elemental calcium, it is the most widely used form of calcium in single ingredient calcium supplements as well as combination supplements. Inexpensive and an abundant source of elemental calcium, it is the only form of calcium found in nature outside of bone. It is the primary form of calcium used in the mass market and in antacid products. This is for people who have high stomach acid and who need a buffering type of calcium. Also for people who want a high dose of calcium in a minimum amount of pills.

calcium citrate: at 21 percent elemental calcium, it is one of the most popular forms of calcium supplements in the health food market as well as the mass market. This calcium salt does not lower stomach acid as much as calcium carbonate. This calcium salt is usually recommended for people who have low stomach acid, have had stomach surgery or who need a form of calcium that will not lower their stomach acid further.

Calcium Gluconate and Lactate: these two forms of calcium are high soluble. Since the amount of elemental calcium is much lower (9 percent and 13 percent respectively), they are used more often in powder form and mixed with liquids or food. When mixed in a beverage, the calcium is already dissolved and is ready to be absorbed. This is the best calcium salt for people who have overactive bowels, who have trouble swallowing pills or who don’t like the taste of pre-formed liquid calcium supplements. These calcium powders can be mixed in juices or smoothies or added to food as they are virtually tasteless.

Calcium Orotate and Asporotate: In the mid 20th century, Dr. Hans Nieper, a German scientist, advanced a theory that orotic and aspartic salt forms of calcium are transported directly to cell membranes for better absorption. The Solaray brand developed an asporotate formula, which combines three organic acids: aspartic acid (-Asp), orotic acid (-oro) and citric acid (-tate) into one product. The asporotate formula has become one of the most popular calcium formulas and is exclusive to the Solaray brand. This product is for customers who appreciate the idea of combining the enhanced absorbability of three organic acids into one. Aspartate and citrate are also part of the krebs (energy) cycle and are natural to the body’s metabolic systems and, according to Neiper, calcium Orotate and Aspartate are mineral transporters that enter into the cells to facilitate enzymatic actions rather than being extra-cellular. For people who believe that intracellular calcium is of importance, calcium Orotate and asporotate may be good choice.

Calcium Hydroxyapatite: this is another “natural form of calcium usually as a mineral ash form bovine source bone. Bone meal is also a form of calcium from bovine bone. These forms of animal derived calcium are for customers who want a source that is closest to their own bone matrix. Not for vegetarians.

Calcium Amino Acid Chelates (*HVP): this form is calcium carbonate bonded (Chelated) to a form of amino acid complex such as whole rice concentrate or other grain source. This form is for customers who want the additional bioavailability of amino acids.

Calcium AEP: Another form of calcium endorsed by Dr. Hans Nieper who theorized that calcium would cross the cell membranes more readily when it was combined with phosphatidyl ethanolamine or Amino Ethanol Phosphate (AEP), a nutrient found in nerve sheaths. This highly specialized form is for very educated customers who are proponets of Hans Niepers theory.

So, which form is best?

Calcium, like cars, comes in a variety of forms. Isn’t it wonderful that we have so many choices? The point is, there is no best one, there are only individual choices. Although we have our favorites, taking a calcium supplement, regardless of which one it is, should:

  • Be a matter of personal choice based on how our body feels when taking it.
  • Be in a form that is most convenient or appetizing so that we receive our daily requirements.
  • Take into consideration any personal body limitations we might have .

Our primary concern when choosing a calcium supplement should be to provide our body with the right amount of calcium daily so that our skeleton and teeth can maintain proper mineralization and strength as the cells continuously break down and rebuild. The type of calcium complex we prefer is entirely up to us.

*HVP = Hydrolyzed Vegetable Protein



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Benefits of Total Daily Formula
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Date: October 13, 2005 04:45 PM
Author: Darrell Miller (dm@vitanetonline.com)
Subject: Benefits of Total Daily Formula

Benefits of Total Daily Formula

Mixed Carotenoids

All fruits and vegetables contain carotenes, the plant pigments responsible for the rich variety of colors we enjoy in the natural world. Beta carotene is the most familiar member of the carotene family. But beta carotene never exists by itself; it is always found with other carotenes in foods. We need more than just beta carotene alone. Carotenes are powerful antioxidants, which means they help reduce the body's free radical burden. Research suggests that carotenes work as a team to keep us healthy.5 Total Daily Formula provides beta carotene, alpha carotene, lutein, lycopene, zeaxanthin and cryptoxanthin from natural sources such as algal extracts, carrot oil, marigold and tomatoes (Caromix®).

Corn-Free Vitamin C

Total Daily Formula uses only corn-free vitamin C (ascorbic acid). The full daily intake of 6 tablets provides an exceptionally generous 800 mg of vitamin C.

Optimum B Vitamin Servings

Total Daily Formula supplies ample amounts of all essential B vitamins. Vitamin B3 is given as niacin plus an extra helping of niacinamide, the non-flush form of this important vitamin. The body uses pantothenic acid (vitamin B5) to deal with stress, so the formula provides 150 mg, which is 15 times the RDA. Vitamin B6 is another B vitamin people may run short of, so 60 mg -- 30 times the RDA -- is supplied. The formula contains 800 mcg of folic acid, the vitamin now recognized by the FDA as essential for prevention of neural tube defects in unborn babies. Folic acid also helps prevent accumulation in the body of homocysteine, a metabolite of the amino acid methionine.6 A high blood homocysteine level is now considered to be a risk factor for heart disease.7

Flavonoids

Flavonoids, also known as "bioflavonoids." are plant pigments widely distributed throughout the plant kingdom.8 Previously known as "Vitamin P," because they help reduce capillary permeability (leakiness) flavonoids are now regarded as "semi-essential" non-vitamin nutrients that benefit health in a variety of ways.9 In addition to maintaining the structure of blood vessels, flavonoids function as versatile antioxidants. Flavonoids protect vitamin C from destruction by free-radicals, helping to preserve the body's vitamin C supply.10 Total Daily Formula provides 100 mg of pure flavonoids from 112 mg of citrus extract.

Three superior sources of Calcium

Total Daily Formula contains three of the best absorbed and most effective forms of calcium available. MCHC (microcrystalline hydroxyapatite concentrate) is a naturally-derived compound composed of calcium, plus all the minerals and organic factors in living bone tissue. MCHC has been clinically shown to benefit bone health.11 calcium citrate malate is a very well-absorbed form of supplemental calcium shown in recent research to be helpful for postmenopausal women.12,13 Calcium glycinate is chelated with the amino acid glycine, one of the most efficient mineral carriers for effective absorption.14,15

Magnesium glycinate

Magnesium is essential for strong bones and healthy hearts. This versatile mineral also regulates nerve function, keeps muscles relaxed and coordinates activity of over 300 enzymes in the body.16 Total Daily Formula contains 100 percent magnesium glycinate for exceptional absorption and gentleness on the intestinal tract.17 Magnesium glycinate has been clinically tested on people with severe malabsorption with excellent results.18

Trace Minerals

Total Daily Formula provides - in addition to zinc, chromium, selenium and iodine - vanadium and molybdenum. Vanadium helps maintain normal blood sugar.19 Molybdenum works as a co-factor for enzymes that help detoxify and eliminate foreign substances from the body.20

Bioperine® for Enhanced Absorption

Bioperine® is a natural extract derived from black pepper that enhances nutrient absorption. Preliminary trials on humans have shown significant increases in the absorption of nutrients consumed along with Bioperine®. 21 Betaine HCL - supplies HCL (hydrochloric acid) to assist digestion. All natural tablet coating made of vegetable concentrate and beta carotene.

Scientific References
1. Cheraskin, E. Ringsdorf, W.M., Clark, J.W. 1968. Diet and Disease. (p. 16). New Canaan, CT: Keats Publishing.

2. Morgan, K.J. et. al. Magnesium and calcium dietary intakes of the U.S. population. Journal of the American College of Nutrition. 1985;4:195-206.

3. Lakschmanan, F.L., Rao, R.B., Kim, W.W., Kelsay, J.L. Magnesium intakes, balances and blood levels of adults consuming self-selected diets. American Journal of Clinical Nutrition 1984;40:1380-89.

4. Mertz, W. The Essential Trace Elements. Fed. Proc. 1970;29:1482.

5. Perry, G. Byers, T. Dietary carotenes, vitamin C and vitamin E as protective antioxidants in human cancers. Annu. Rev. Nutr. 1992;12:139-59.

6. Landgren, F., et. al. Plasma homocysteine in acute myocardial infarction: Homocysteine-lowering effect of folic acid. J Int Med 1995;237:381-88.

7. Clarke, R., et. al. Hyperhomocysteinemia: an independent risk factor for vascular disease. New Eng J Med 1991;324:1149-55. 8. Havsteen, B. Flavonoids, a class of natural compounds of high pharmacological potency. Biochemical Pharmacology 32(7):1141-48.

9. Middleton, E. The flavonoids. TIPS 1984; 5:335-38.

10. Roger, C.R. The nutritional incidence of flavonoids: some physiological and metabolic considerations. Experientia 44(9):725-804.

11. Dixon, A. St. J. Non-hormonal treatment of osteoporosis. British Medical Journal 1983;286(6370):999-1000.

12. Smith, K.T. et. al. Calcium Absorption from a new calcium delivery system (CCM). Calcif Tissue Int 1987;41:351-352.

13. Dawson-Hughes, B. et. al. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. New England Journal of Medicine 1990 Sep 27;323(13):878-883.

14. Albion Research Notes Vol. 4, No. 1, ©Albion Laboratories Jan,1995.

15. Ashmead, H.D. Intestinal Absorption of Metal Ions and Chelate, Springfield: Charles C Thomas, ©1985.

16. Wester, P.O., Dyckner, T. The importance of the magnesium ion. Magnesium deficiency-symptomatology and occurrence. Acta Med Scand 1992; (Suppl) 661:3-4.

17. Albion Research Notes Vol. 3, No. 1, ©Albion Laboratories, Feb 1994.

18. Schutte, S., et. al. Bioavailability of Mg diglycinate vs MgO in patients with ileal resections. Abstract 115, AJCN 1992;56(4).

19. Cohen, N. et. al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J. Clin Invest 1995; 95:2501-09.

20. Sardesi, V.M. Molybdenum: An essential trace mineral element. Nutr Clin Pract 1993; 8:277-81.

21. Bioperine® - Nature's Bioavailability Enhancing Thermo-nutrient. Executive Summary' 1996; Sabinsa Corporation, Piscataway, N.J.



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